Nintil

Links (94)

Brief

Nintil’s Links (94) (24 Dec 2025) aggregates short notes on biotech, AI, and space economics: frog‑derived bacteria beat doxorubicin and checkpoint inhibitors in mice, a phase‑3 vagus‑nerve stimulation trial reportedly yielded FDA approval for rheumatoid arthritis, and hyperscalers face strained free cash flow after large AI capex; also covered are CAR‑T for cardiovascular disease, proteomics clocks, and LLM interpretability debates.

Why it matters

Bacteria isolated from Japanese tree frogs reportedly outperform doxorubicin and checkpoint inhibitors in mouse cancer models (Nintil, 2025-12-24).

Key details

  • A phase‑3 trial of vagus nerve stimulation showed benefit in rheumatoid arthritis and is reported to have led to FDA approval (Nintil, 24 Dec 2025).
  • Hyperscaler free cash flow is weakening after heavy AI capital expenditures, raising concerns about cloud providers’ financial sustainability and AI capex returns (Nintil, 2025).
Source evidence

title: Links (94)
contenttype: article
publication: Nintil
published: 2025-12-24T00:00:00+00:00
source
url: https://nintil.com/links-94/

word_count: 297

Bacteria isolated from japanese tree frogs shown to work better in mice against cancer than doxorubicin or checkpoint inhibitors CAR-T to treat cardiovascular disease New proteomics clock, I wrote a brief thread with some commentary On the (deranged, imho) economics of space-based data centers; Elon likes the idea but he'll be proven wrong on this one: DSHR 's blog, with an observation I had been thinking about for a while but not seen addressed elsewhere: accounting for Kessler syndrome Scott Manley ( 1 , 2 ) Andrew McCalip and thread Scott Aaronson: "[seeking understanding of the universe] It’s self-indulgent, a few steps above spending my life learning to solve Rubik’s Cube as quickly as possible, but only a few". The comments are also an interesting read. On peptides , from Eric Topol On mechanistic interpretability of LLMs as a dead end Progress in predicting binding affiniy of small molecules to proteins Amanda Askell answers various philosophical questions about LLMs Vagus nerve stimulation , in a phase 3 clinical trial, helps with rheumathoid arthritis, making this FDA approved. Score one for the woo claim that the mind influences what otherwise might be thought of as merely biological processes, disconnected from thoughts. To the contrary, the brain is not only concerned with cognition or locomotion but rather most things that happen in the body! How are LLMs trained these days (as of 2024 at least) An explanation of the phenomenon of grokking in LLMs Butoh , a quaint japanese dance form Olms , similar to Axolotls are salamanders that are extremely long lived and have regenerative capacities A deeply moving post from Aella on the death of her mom Hyperscaler free cash flow is running dry after all that spending on AI Capex Review of LLM progress in 2025